Evaluation in silico du profil toxicologique de quelques molécules isolées de Aloe vera et de la pastèque (Citrullus lanatus) utilisées dans la formulation des crèmes solaires - CSN

Evaluation in silico du profil toxicologique de quelques molécules isolées de Aloe vera et de la pastèque (Citrullus lanatus) utilisées dans la formulation des crèmes solaires

Publication Date : 29/06/2024

DOI: 10.59228/rcst.024.v3.i2.76


Author(s) :

Aristote Matondo, Christian V. Mulombela, Mardochée M. Kadima, Kelly T. Mwanda, Mbanga Lokebo, Hilaire V.S. Mambo, Pierre O. Lohohola, Damien S.T. Tshibangu, Koto-Te-Nyiwa Ngbolua, Sylvie-Mireille N. Bambi, Pius T. Mpiana.


Volume/Issue :
Volume 3
,
Issue 2
(06 - 2024)



Abstract :

Medical Cutaneous pharmacokinetics and toxicology are important in cosmetology, because the harmful effects of ultraviolet light require external photoprotection, such as sunscreens containing sunscreens. However, some of these compounds are toxic to the skin. As a result, natural plant-based products are increasingly being studied for their low toxicity. This study used bioinformatics tools to assess the toxicity of six molecules, three from Aloe vera and three from watermelon. With the exception of lycopene, all the molecules have a good toxicological profile. Computational approaches are presented are presented as rapid and inexpensive tools for making predictions basis for future experimental studies.


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