Author(s) :

Arold Fazili, Davina NGONGA, Armand ABASI, Gradine Mujinga.

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Abstract :

Tuberculosis (TB) remains a major health challenge in DR Congo, triggering systemic inflammatory and hemostatic disruptions. This study aims to analyze variations in ferritin, INR, and D-dimers to understand the infection's impact on iron metabolism and blood coagulation. A cross-sectional analytical study was conducted at the DeeService Medical Laboratory in Lubumbashi involving 60 participants: 30 GeneExpert-confirmed TB patients and 30 healthy controls. Ferritin and D-dimers were measured using quantitative immunofluorescence (Finecare™), while INR was determined via mechanical detection. Due to non-normal data distribution (Shapiro-Wilk, p < 0.05), the Mann-Whitney U test was used for intergroup comparisons. TB patients showed significantly higher levels compared to controls (p < 0.001) for all parameters: Ferritin (364.52±146.65 vs 111.36 ±39.97 µg/L), D-dimers (1078.25±867.60 vs 337.83±136.72 ng/mL), and INR (1.65±0.40 vs 0.76±0.093). A significant positive correlation was found between ferritin and D-dimers (r_s = 0.400; p = 0.014), reflecting a "thrombo-inflammatory" state. Active tuberculosis in Lubumbashi induces a profound hemostatic imbalance and hyperinflammation. Monitoring these biomarkers could improve clinical severity assessment and the prevention of thrombotic complications.

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